{"id":198,"date":"2011-12-17T18:42:27","date_gmt":"2011-12-17T18:42:27","guid":{"rendered":"https:\/\/impact-r.com\/?p=198"},"modified":"2025-07-22T12:07:25","modified_gmt":"2025-07-22T12:07:25","slug":"impact-r-to-monitor-aspirin-use-in-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/impact-r.com\/?p=198","title":{"rendered":"Impact-R to Monitor Aspirin Use in Diabetes Mellitus"},"content":{"rendered":"<p>One of the risk factors for cardiovascular disease is Diabetes. In fact, there is a 2-4 fold increase in the risk of dying from heart disease if the patient is diabetic. One of the reasons is increased production of thromboxane which is a vasoconstrictor and at the same time promotes platelet aggregation.<\/p>\n<div id=\"attachment_200\" style=\"width: 250px\" class=\"wp-caption alignright\"><a href=\"https:\/\/impact-r.com\/wp-content\/uploads\/2011\/12\/aspirin1.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-200\" class=\"size-medium wp-image-200\" src=\"https:\/\/impact-r.com\/wp-content\/uploads\/2011\/12\/aspirin1-240x300.jpg\" alt=\"\" width=\"240\" height=\"300\" srcset=\"https:\/\/impact-r.com\/wp-content\/uploads\/2011\/12\/aspirin1-240x300.jpg 240w, https:\/\/impact-r.com\/wp-content\/uploads\/2011\/12\/aspirin1.jpg 346w\" sizes=\"auto, (max-width: 240px) 100vw, 240px\" \/><\/a><p id=\"caption-attachment-200\" class=\"wp-caption-text\">Acetylsalicylic acid (Aspirin).<\/p><\/div>\n<p>Aspirin, or acetylsalicylic acid is a non-steroidal anti-inflammatory drug that has many effects. It is an anti-pyretic, an analgesic and, an anti-inflam-matory drug. It also acts as an anti-platelet because it irreversibly inhibits the&nbsp;&nbsp;formation of thromboxane through the cyclooxygenase I pathway.<\/p>\n<p>The American Diabetes Association and the American Heart Association have endorsed the following guidelines: &#8220;Aspirin may be used in women over 60 and men over 50 who have diabetes mellitus who have other risk factors for heart attack and stroke.&#8221;<\/p>\n<p>A study by Spectre, et.al. showed that twice daily dosing of aspirin improved the laboratory outcomes in high-risk DM II patients. The laboratory parameters used were impedance aggregometry (WBA) and the <a href=\"https:\/\/impact-r.com\/impact-r-laboratory-platelet-function-cone-and-plate-analyser\/\" target=\"_blank\" rel=\"noopener noreferrer\">IMPACT-R<\/a> (CPA). An abstract of the study can be found <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21800009\" target=\"_blank\" rel=\"noopener noreferrer\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the risk factors for cardiovascular disease is Diabetes. In fact, there is a 2-4 fold increase in the risk of dying from heart disease if the patient is diabetic. One of the reasons is increased production of thromboxane which is a vasoconstrictor and at the same time promotes platelet aggregation. Aspirin, or acetylsalicylic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[90,91,93,94,70,95,92,96],"class_list":["post-198","post","type-post","status-publish","format-standard","hentry","category-disorders-use-of-impact-r-in-research","tag-aspirin","tag-diabetes-mellitus","tag-dm-ii","tag-heart-attack","tag-impact-r","tag-stroke","tag-t2dm","tag-thromboxane"],"_links":{"self":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=198"}],"version-history":[{"count":7,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/198\/revisions"}],"predecessor-version":[{"id":378,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/198\/revisions\/378"}],"wp:attachment":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}