{"id":261,"date":"2011-12-29T15:58:24","date_gmt":"2011-12-29T15:58:24","guid":{"rendered":"https:\/\/impact-r.com\/?p=261"},"modified":"2025-07-22T12:11:13","modified_gmt":"2025-07-22T12:11:13","slug":"impact-r-and-heyde-syndrome","status":"publish","type":"post","link":"https:\/\/impact-r.com\/?p=261","title":{"rendered":"Impact-R and Heyde Syndrome"},"content":{"rendered":"<p>This is a case of a 79-year old man with severe aortic stenosis and recurrent GI bleeding. This <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19012181\" target=\"_blank\" rel=\"noopener noreferrer\">case study by Schmid, et.al.<\/a> proposes that <a href=\"https:\/\/impact-r.com\/impact-r-laboratory-platelet-function-cone-and-plate-analyser\/\" target=\"_blank\" rel=\"noopener noreferrer\">Impact-R<\/a> to determine platelet function may be more time- and cost-effective compared to electrophoretic analysis of vWF multimers.<\/p>\n<p>Severe aortic stenosis with bleeding diathesis is also known as Heyde syndrome. The pathophysiology: loss of high molecular weight vWF multimers in high shear stress conditions leads to a platelet type von Willebrand disease (<a href=\"https:\/\/impact-r.com\/impact-r-and-acquired-von-willebrand-disease-in-severe-aortic-stenosis\/\" target=\"_blank\" rel=\"noopener noreferrer\">acquired vWD, vWD type 2B<\/a>) which can explain the bleeding tendencies of a patient with severe aortic stenosis.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This is a case of a 79-year old man with severe aortic stenosis and recurrent GI bleeding. This case study by Schmid, et.al. proposes that Impact-R to determine platelet function may be more time- and cost-effective compared to electrophoretic analysis of vWF multimers. Severe aortic stenosis with bleeding diathesis is also known as Heyde syndrome. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[117,70,82,47,105],"class_list":["post-261","post","type-post","status-publish","format-standard","hentry","category-disorders-use-of-impact-r-in-research","tag-heyde-syndrome","tag-impact-r","tag-platelet-aggregation","tag-vwd","tag-vwf-multimers"],"_links":{"self":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=261"}],"version-history":[{"count":3,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/261\/revisions"}],"predecessor-version":[{"id":393,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/261\/revisions\/393"}],"wp:attachment":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}