{"id":264,"date":"2012-01-02T12:19:21","date_gmt":"2012-01-02T12:19:21","guid":{"rendered":"https:\/\/impact-r.com\/?p=264"},"modified":"2025-07-22T12:05:04","modified_gmt":"2025-07-22T12:05:04","slug":"impact-r-test-for-agonist-induced-platelet-aggregation","status":"publish","type":"post","link":"https:\/\/impact-r.com\/?p=264","title":{"rendered":"Impact-R Test for Agonist-induced Platelet Aggregation"},"content":{"rendered":"<div id=\"attachment_265\" style=\"width: 310px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-265\" class=\"size-medium wp-image-265\" src=\"https:\/\/impact-r.com\/wp-content\/uploads\/2012\/01\/thrombin-300x205.jpg\" alt=\"\" width=\"300\" height=\"205\" srcset=\"https:\/\/impact-r.com\/wp-content\/uploads\/2012\/01\/thrombin-300x205.jpg 300w, https:\/\/impact-r.com\/wp-content\/uploads\/2012\/01\/thrombin.jpg 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><p id=\"caption-attachment-265\" class=\"wp-caption-text\">Thrombin is a powerful platelet agonist.<\/p><\/div>\n<p>Impact R is a useful tool to assess platelet function in different hematologic diseases and to monitor anti-platelet therapy.&nbsp; In the <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18925512\" target=\"_blank\" rel=\"noopener noreferrer\">study by Shenkman, et.al.<\/a>, Impact-R was used to test agonist-induced platelet aggregation.<\/p>\n<p>Some of the known platelet agonists are: ADP, epinephrine, arachidonic acid, gamma-thrombin, and collagen. In the aforementioned study, they used ADP, ristocetin, epinephrine, collagen and arachidonic acid. These agonist act through various mechanisms that affect different stages of the coagulation process.<\/p>\n<p>The Impact-R agonist response test detected platelet aggregation defects in patients with storage pool disease, von Willebrand disease and epinephrine response deficiency.&nbsp; It may be useful in determining response to various platelet agonists.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Impact R is a useful tool to assess platelet function in different hematologic diseases and to monitor anti-platelet therapy.&nbsp; In the study by Shenkman, et.al., Impact-R was used to test agonist-induced platelet aggregation. Some of the known platelet agonists are: ADP, epinephrine, arachidonic acid, gamma-thrombin, and collagen. In the aforementioned study, they used ADP, ristocetin, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[70,83,82,118],"class_list":["post-264","post","type-post","status-publish","format-standard","hentry","category-usage-of-impact-r","tag-impact-r","tag-platelet-adhesion","tag-platelet-aggregation","tag-platelet-agonists"],"_links":{"self":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=264"}],"version-history":[{"count":3,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/264\/revisions"}],"predecessor-version":[{"id":377,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/264\/revisions\/377"}],"wp:attachment":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}