{"id":327,"date":"2012-03-01T13:02:04","date_gmt":"2012-03-01T13:02:04","guid":{"rendered":"https:\/\/impact-r.com\/?p=327"},"modified":"2025-07-22T12:09:26","modified_gmt":"2025-07-22T12:09:26","slug":"impact-r-and-inherited-combined-deficiency-of-vitamin-k-dependent-clotting-factors","status":"publish","type":"post","link":"https:\/\/impact-r.com\/?p=327","title":{"rendered":"Impact-R and Inherited Combined Deficiency of Vitamin K Dependent Clotting Factors"},"content":{"rendered":"<p>Impact-R, a cone and plate analyzer may be of benefit in the monitoring of treatment of VKCFD or Vitamin K Dependent Clotting Factor Deficiency.<\/p>\n<p>VKCFD is a rare autosomal recessive deficiency of Vitamin K dependent factors. This means a deficiency of the clotting factors II, VII, IX and X. This disorder was first described in a female infant who exhibited significant bleeding during the first week of life.<\/p>\n<div id=\"attachment_329\" style=\"width: 184px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/impact-r.com\/wp-content\/uploads\/2012\/03\/vitk1.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-329\" class=\"wp-image-329 size-full\" src=\"https:\/\/impact-r.com\/wp-content\/uploads\/2012\/03\/vitk1.jpg\" alt=\"\" width=\"174\" height=\"147\"><\/a><p id=\"caption-attachment-329\" class=\"wp-caption-text\">Vitamin K.<\/p><\/div>\n<p>Vitamin K dependent factors require ?-carboxylation of glutamic acid residues at their Gla domains to enable binding of calcium to phospholipid membranes. This reaction is catalyzed by an enzyme, ?-glutamyl carboxylase. This enzyme requires reduced Vitamin K as a cofactor.<\/p>\n<p>VKCFD may be difficult to diagnose in newborns because of the routine administration of Vitamin K at birth. VKCFD may be treated by oral or parenteral Vitamin K but there may be cases where Vitamin K does not improve symptoms and factor replacement may be necessary.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Impact-R, a cone and plate analyzer may be of benefit in the monitoring of treatment of VKCFD or Vitamin K Dependent Clotting Factor Deficiency. VKCFD is a rare autosomal recessive deficiency of Vitamin K dependent factors. This means a deficiency of the clotting factors II, VII, IX and X. This disorder was first described in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[171,173,172,174,170],"class_list":["post-327","post","type-post","status-publish","format-standard","hentry","category-disorders-use-of-impact-r-in-research","tag-factor-ii-deficiency","tag-factor-ix-deficiency","tag-factor-vii-deficiency","tag-factor-x-deficiency","tag-vkcfd"],"_links":{"self":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=327"}],"version-history":[{"count":5,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/327\/revisions"}],"predecessor-version":[{"id":430,"href":"https:\/\/impact-r.com\/index.php?rest_route=\/wp\/v2\/posts\/327\/revisions\/430"}],"wp:attachment":[{"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-r.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}